Virtus Health maintains a demonstrable commitment to research in the area of assisted reproductive services - hundreds of papers have been published by members of our group over the past couple of decades. Our focus is on providing applied research, and we continue to lead the way in contributions to IVF and Assisted Reproductive Technology (ART) research.
Recent Scientific Publications in Peer Reviewed Scientific Journals & Books:
LH Supplementation for Low LH Levels during Antagonist IVF Cycles Improves Live Birth Rates. Conrad C, Hughes G, Sacks G. JFIV Reprod Med Genet 2015; 3: 155.
Sperm DNA fragmentation abnormalities in men from couples with a history of recurrent miscarriage. Leach M, Aitken RJ, Sacks G. Aust N Z J Obstet Gynaecol. 2015 Aug;55(4):379-83.
Elective Single Embryo Transfer: an update to UK Best Practice Guidelines, Harbottlea S, Hughes C, Cutting R, Roberts S, Brisone D. Human Fertility. 2015; 18, 3: 165-183.
Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial. Rodda CP, Benson JE, Vincent AJ, Whitehead CL, Polyakov A and Vollenhoven B. Clinical Endocrinology. 2015; 83: 363-368
Asynchronous glands in the endometrium of women with recurrent reproductive failure. Russell P, Hey-Cunningham A, Berbic M, Tremellen K, Sacks G, Gee A, Cheerala B. Pathology. 2014 Jun;46(4):325-32.
Single-arm, observational study of the ease of use of a redesigned pen device to deliver recombinant human follicle-stimulating hormone (follitropin alfa) for assisted reproductive technology treatment. Illingworth PJ1, Lahoud R1, Quinn F1, Chidwick K2, Wilkinson C2, Sacks G.Patient Prefer Adherence. 2014 Jun 5;8:813-26.
The clinical effectiveness of preimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A): systematic review. Lee E, Illingworth P, Wilton L and Chambers GM. Human Reproduction. 2014.
Motivations and experiences of patients seeking cross-border reproductive care: the Australian and New Zealand context. Rodino IS, Goedeke S and Nowoweiski S. Fertility and Sterility. 2014; 102: 1422-1431.
The Impact of Uterine Radiation on Subsequent Fertility and Pregnancy Outcomes. Teh WT, Stern C, Chander S and Hickey M. BioMed Research International. 2014; 482968.
Impact of oxygen concentration on adult murine pre-antral follicle development in vitro and the corresponding metabolic profile. Gook DA, Edgar DH, Lewis K, Sheedy JR and Gardner DK. Molecular Human Reproduction. 2014; 20: 31-41.
Delivery of twins following heterotopic grafting of frozen-thawed ovarian tissue. Stern CJ, Gook D, Hale LG, Agresta F, Oldham J, Rozen G and Jobling T. Human Reproduction. 2014; 29: 1828.
Women's reflections on fertility and motherhood after breast cancer and its treatment. Kirkman M, Winship I, Stern C, Neil S, Mann GB and Fisher JR. European Journal of Cancer Care. 2014; 23: 502-513.
Comparing indicators of health and development of singleton young adults conceived with and without assisted reproductive technology. Halliday J, Wilson C, Hammarberg K, Doyle LW, Bruinsma F, McLachlan R, McBain J, Berg T, Fisher JR and Amor D. Fertility and Sterility. 2014; 101: 1055-1063.
A randomised controlled trial of intra-uterine insemination versus in vitro fertilisation in patients with idiopathic or mild male infertility. Elzeiny H, Garrett C, Toledo M, Stern K, McBain J and Baker HWG. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2014; 54: 156-161.
Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro. Natesan SA, Bladon AJ, Coskun S, Qubbaj W, Prates R, Munne S, Coonen E, Dreesen JC, Stevens SJ, Paulussen AD, Stock-Myer SE, Wilton LJ, Jaroudi S, Wells D, Brown AP and Handyside AH. Genetics in Medicine 2014; 16: 838-845.
Clinical outcomes following cryopreservation of blastocysts by vitrification or slow freezing: a population-based cohort study. Li Z, Wang YA, Ledger W, Edgar DH and Sullivan EA. Human Reproduction 2014; 29: 2794-2801.
The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. III: Further observations and reference ranges. Russell P, Sacks G, Tremellen K, Gee A. Pathology. 2013 Jun;45(4):393-401.
Reproductive Concerns Of Children And Adolescents With Cancer: Challenges and potential solutions. Stern C, Conyers R, Orme L, Barak S, Agresta F and Seymour J. Clinical Oncology in Adolescents and Young Adults. 2013; 3: 63–78
Which women develop urgency or urgency urinary incontinence following midurethral slings? Lee JK, Dwyer PL, Rosamilia A, Lim YN, Polyakov A, Stav K. Int Urogynecol. 2013; 24(1):47-54
First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy. Stern CJ, Gook D, Hale LG, Agresta F, Oldham J, Rozen G, Jobling T. Human Reproduction 2013
The relationship between serum prolactin concentration and pregnancy outcome in women with unexplained recurrent miscarriage. Li W, Ma N, Laird S, Ledger WL & Li TC. Journal of Obstetrics and Gynaecology 2013.
Laparoscopic Subtotal Hysterectomy: Evidence and Techniques. Nesbitt-Hawes EM, Maley PE, Ryun Won H, Law KS, Zhang CS, Lyons SD, Ledger WL & Abbott JA. Journal of Minimally Invasive Gynecology 2013; 20:424-434.
Sperm DNA fragmentation in men with malignancy. McDowell S, Harrison K, Kroon B, Ford E, Yazdani A. Fertil Steril 2013; 99:1862-1866.
Clinical value of sperm DNA damage should be assessed in motile sperm fraction rather than whole ejaculated sperm. Liu DY, Liu ML. Fertil Steril 2013;99:367-371.
Defective protein kinase A and C pathways are common causes of disordered zona pellucida (ZP)--induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding. Liu DY, Liu ML, Baker HWG. Fertil Steril. 2013;99:86-91.
Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos. Mertzanidou A, Wilton L, Cheng J, Spits C, Vanneste E, Moreau Y, et al. Hum Reprod. 2013;28:256-64.
Pregnancy-specific anxiety, ART conception and infant temperament at 4 months post-partum. McMahon CA, Boivin J, Gibson FL, Hammarberg K, Wynter K, Saunders D, Fisher, J. Hum Reprod. 2013;28:997-1005.
Fertility management after breast cancer diagnosis: a qualitative investigation of women's experiences of and recommendations for professional care. Kirkman M, Stern C, Neil S, Winship I, Mann GB, Shanahan K, Missen D, Shepherd H, Fisher JR. Health Care Women Int. 2013;34:50-67.
Metformin versus clomiphene citrate for infertility in non-obese women with PCOS: a systematic review and meta-analysis. Misso ML, Costello MF, Garrubba M, Wong J, Hart R, Rombauts L, Melder AM, Norman RJ, Teede HJ. Human Reproduction Update. 2013; 19(1):2-11
An analysis of the impact of embryo transfer difficulty on live birth rates, using a standardised grading system. Dave R Listijono, Tim Boylan, Simon Cooke, Suha Kilani, Michael G Chapman. Human Fertility . 2013; DOI:10.3109/14647273.2013.804956
Ovarian stimulation protocols for onco-fertility patients. Koch J, Ledger W. Assist Repro Gen. 2013; 30:2;203-6
Prednisolone for repeated implantation failure associated with high natural killer cell levels: Case Report and Risk-Benefit analysis. Krigstein M, Sacks G. J Obstet Gynaecol 2012;32:518-9.
Acupuncture to improve live birth rates for women undergoing in vitro fertilisation a protocol for a randomised controlled trial. Smith C, de Lacey S, Chapman M, Ratcliffe J, Norman R, Johnson N, Sacks G, Lyttleton J, Boothroyd C. Trials 2012;13:60.
Comparative usage of a web-based personally controlled health management system and normal support: a case study in IVF. Lau A, Parker A, Early J, Sacks G, Anvari F, Coiera E. Electronic J Health Informatics 2012;7(2):e12
Detailed analysis of peripheral blood natural killer cells in women with repeated IVF failure. Sacks GP, Yang Y, Gowen E, Smith S, Fay L, Chapman M.Am J Reprod Immunol. 2012 May;67(5):434-42.
Fleming T, Sacks GP, Nasser J. Internal Jugular Vein Thrombosis Following Ovarian Hyperstimulation Syndrome. Aust N Z J Obstet Gynaecol. 2012;52(1):87-90
A qualitative study of HIV serodiscordant patients accessing assisted reproductive treatment. Peak S, Nowoweiski S, & Giles M. Journal of Reproductive and Infant Psychology. 2012;Vol. 30,No. 4,413–422.
Consensus on current management of endometriosis. Johmon N.P, Hummelshoj, L Tsaltis, J, et al. Human Reproduction . 2012; 28(6):1552 – 68
Comparison of Ultrasonic Shears and traditional suture ligasure for vaginal hysterectomy: A randomised controlled trial. Fitzgerald A, Tsaltas J, Tan J et al. Journal of Minimally Invasive Gynaecology. 2012
The accuracy of spot urinary protein-to-creatinine ratio in confirming proteinuria in pre-eclampsia. Cade TJ, Gilbert SA, Polyakov A, Hotchin A. Aust N Z J ObstetGynaecol. 2012; Apr;52(2):179-82.
Does pre-operative traction on the cervix approximate intra-operative uterine prolapse? A randomised controlled trial. Chao FL, Rosamilia A, Dwyer PL, Polyakov A, Schierlitz L, Agnew G. IntUrogynecol J . 2012; Apr;23(4):417-22.
Status of clomiphene citrate and metformin for infertility in PCOS. Misso ML, Teede HJ, Hart R, Wong J, Rombauts L, Melder AM, Norman RJ, Costello MF. Trends in Endocrinology and Metabolism. 2012; 23(10):533-543
Aromatase inhibitors for PCOS: a systematic review and meta-analysis. Misso ML, Wong J, Teede HJ, Hart R, Rombauts L, Melder A, Norman RJ, Costello MF. Hum Reprod. 2012; 18:301-312.
The molecular chaperone hspa2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition. Redgrove KA, Nixon B, Baker MA, Hetherington L, Baker G, Liu DY, Aitken JR. PLOS One, November 2012; 7 (11): e50851. www.plosone.org
The Alpha consensus meeting on cryopreservation key performance indicators and benchmarks: proceedings of an expert meeting. Balaban B, Edgar DH, et al. Reprod Biomed Online. 2012;25:146-67.
Assisted Reproductive Technology - What's new and what's important? Stern K. Aust Fam Physician. 2012;41(10):762-8.
The ESHRE PGD Consortium: 10 years of data collection. Harper JC, Wilton L, Traeger-Synodinos J, Goossens V, Moutou C, SenGupta SB Hum Reprod Update. 2012;18: 234-47.
Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Castrechini NM, Murthi P, Qin S, Kusuma GD, Wilton L, Abumaree M. Reprod Sci. 2012;19:1302-14.
Single embryo transfer reduces the risk of perinatal mortality, a population study. Sullivan EA, Wang YA, Hayward I, Chambers GM, Illingworth P, McBain J, Norman RJ. Hum Reprod. 2012;27:3609-15.
Admissions for early parenting difficulties among women with infants conceived by assisted reproductive technologies: a prospective cohort study. Fisher JR, Rowe H and Hammarberg K Fertil Steril. 2012;97:1410-6.
A critical appraisal of cryopreservation (slow cooling versus vitrification) of human oocytes and embryos. Edgar DH and Gook DA. Hum Reprod Update 2012;18(5):536-54.
Elevated progesterone in GnRH agonist down regulated in vitro fertilisation (IVF/ICSI) cycles reduces live birth rates but not embryo quality. Lahoud R, Kwik M, Ryan J, Al-Jefout M, Foley J, Illingworth P. Arch Gynecol Obstet. 2012 Feb;285(2):535-40.
Detailed Analysis of Peripheral Blood Natural Killer Cells in Women with Repeated IVF Failure. Sacks G, Yang Y, Gowen E, Smith S, Fay L, Chapman M. Am J Reprod Immunol 2012; 67: 434–442
Internal jugular vein thrombosis following ovarian hyperstimulation syndrome. Fleming T, Sacks GP, Nasser J. Aust N Z J Obstet Gynaecol. 2012;52(1):87-90
Detailed analysis of peripheral blood natural killer cells in women with repeated IVF failure. Sacks GP American Journal of Reproductive Immunology - AJI-1105
Evidence based management of infertility in women with polycystic ovary syndrome using surgery or assisted reproductive technology. Michael F Costello & William L Ledger Women’s Health 2012 8(3), 291-300
Evidence based lifestyle and pharmacological management of infertility in women with polycystic ovary syndrome. Michael F Costello & William L Ledger. Women’s Health 2012;8:277-290
The treatment of infertility in polycystic ovary syndrome: a brief update. Costello MF, Misso ML, Wong J, Hart R, Rombauts L, Melder A, Norman RJ, Teede HJ Aust NZ J Obstet Gynaecol 52:400-403;2012
Post-mortem sperm retrieval in Australia. Kroon B, Kroon F, Holt S, Wong B, Yazdani A. Aust NZ J Obstet Gynaecol 52:487-490;2012
Antibiotics prior to embryo transfer in ART. Ben Kroon, Roger J Hart, Brittany Wong, Emily Ford, Anusch Yazdani. Editorial Group: Cochrane Menstrual Disorders and Subfertility Group. Published Online: 14 Mar 2012, DOI: 10.1002/14651858.CD008995.pub2
CFTR mutation screening in an assisted reproductive clinic. Field PD, Martin NJ. Aust NZ J Obstet Gynaecol 51:536-539;2011
The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure I: Techniques. Russell P, Anderson L, Lieberman D, Tremellon K, Yilmaz H, Cheerala B, Sacks GP. J Reprod Immunol. 2011;91:90-102.
Use of Comparative Genomic Hybridization (CGH) and Microarray CGH for Preimplantation Genetic Screening. Leeanda Wilton and Dagan Wells. In D.K. Gardner et al. (eds.), Human Gametes and Preimplantation Embryos: Assessment and Diagnosis, Springer Science+Business Media New York, 2013
Sperm Assessment: Novel Approaches and Their Indicative Value. Liu DY, Bourne H, Garrett C, Clarke G, Barak S and Baker HWG. In: Nagy ZP, Varghese AC and Agarwal A (eds) Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices, Springer Science+Business Media, LLC 2012, pp193-198.
Human acrosome reaction, abnormal sperm and cause of failure of fertilization in ICSI. Liu DY. In: Huang GN, Sun HX (eds) Laboratory Technical Manual of In Vitro Fertilization and Embryo Transfers (in Chinese), People’s Medical Publishing House, China, 2012.
Surgical Therapies; Rectal/Bowel Endometriosis. Tsaltas J. Endometriosis Science and Practice, Wiley-Blackwell Blackwell Publishing, 2012
Psychological Implications of Infertility and Assisted Reproductive Technologies (ART), Nowoweiski S. In Caltabiano & Ricciardelli (Eds.) Applied Topics in Health Psychology. Wiley Publications, 2012